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The molecular interactomes that underpin pressure-sensitive and insensitive aspects of POAG remain to be fully characterized with potential clues from recent genome-wide association study (GWAS) analyses of adult-onset POAG loci including genes that encode cholesterol-binding caveolin proteins CAV1/2, ABCA1 (ATP-binding cassette transporter 1), TGFBR3 (transforming growth factor beta receptor 3), FOXC1 (forkhead box C1), ELOVL5 (elongation of long chain fatty acids family member 5), ATOH7 (atonal homolog 7), CYP1B1 (a cytochrome P450 enzyme) and ATXN2 (ataxin isoform 2) proteins

As the hormonal effector of the circadian system, melatonin plays a multifaceted role in coordinating sleep and other rhythms ( Circadian alterations observed during aging exist along a continuum ranging from adaptive reorganization to maladaptive disruption

Ann Emerg Med 1991;20:1058-1063

Smaller syringes with finer gradations offer improved accuracy for very small doses

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