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Description

Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease

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Age-associated loss of Sirt1-mediated enhancement of glucose-stimulated insulin secretion in beta cell-specific Sirt1-overexpressing (BESTO) mice

Within experimental models, it is commonly investigated for its interaction with peptide-mediated signalling networks and molecular mechanisms

In some embodiments, the invention encompasses a method of inhibiting NNMT in vitro or in vivo by contacting a cell expressing NNMT with one or more cations of the invention