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319 Additionally, these exosomes may influence the biological phenotypes of other OA-related cells, such as synovial fibroblasts (SFB) and macrophages

The BMP/Smad pathway effect is counteracted by the transplantation of MSCs derived from bone marrow (BMSCs), which promote NSC differentiation into OLs, the myelinating glia of the CNS (Sandner et al., 2013