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GSH is both a necessary cofactor for GPX4 to inhibit ferroptosis and the primary buffer for chelating copper ions in the cell

doi: 10.1016/j.jddst.2023.105067, PMID: 39780956 [DOI] [Google Scholar] 155.Houldsworth A

The function of GSTP1 is to catalyze the binding of GSH to various electrophilic hydrophobic substances to form water-soluble compounds for excretion from the body ( Therefore, we speculate that lung cancer cells might form a GSTP1-Keap1-Nrf2 positive feedback loop under ionizing radiation or oxidative stress, and play an anti-oxidative damage effect

These adverse events can affect most human organ systems and may occur any time after starting immune checkpoint inhibitor therapy