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The largest active component, TQ, makes up 30-48 percent of the essential oil of black seed oil, and offers the main biologic and pharmacologic effects

Gut bacteria hydrolyze AC into bioactive metabolites, particularly caffeic acid and hydroxytyrosol, which possess well-documented antioxidant, anti-inflammatory (Jalal et al

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Consequently, PGC-1 activates NRF1 and PPAR, driving mitochondrial biogenesis and adaptive metabolism, leading to metabolic reprogramming

In this 24-month, double-masked, prospective study, participants were randomly assigned to PBM or sham treatment groups (2:1) and received one series of treatment (nine sessions delivered three times a week over 3 to 5 weeks) every 4 months