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Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases

The metabolically stabilized 6-AH family member, D-Nle-Tyr-Ile-NH-(CH 2 ) 5 -CONH 2 , had a t| /2 in blood of 80 min compared to the parent compound Norleual (Nle-Tyr-Leu-T-(CH 2 -N) 3 -His-Pro-Phe, SEQ ID NO: 1), which had a tj 2 in blood of Cm ax concentration in plasma extrapolated to time zero (Co), terminal elimination half-life (ti 2 ), volume of distribution (Vd), and clearance (CL)

Goldberg, a clinical professor of dermatology at the Mount Sinai School of Medicine states, Over 100 scientific articles confirm hydroquinone is a safe topical for humans