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Adipose tissue macrophages (ATMs) surrounding dead adipocytes cause obesity-induced inflammation and secrete pro-inflammatory cytokines leading to local insulin resistance in adipose tissues ( via the stress-responsive c-Jun-NH2-terminal kinase (JNK 1/2), inhibitor of B kinase (IKK) and mitogen-activated protein kinase (MAPK) p38 ( Moreover, obesity-induced inflammation can lead to insulin resistance in the skeletal muscle or liver, resulting in systemic insulin resistance ( Recent studies suggest that the PPP might serve as a novel and promising target for modulating obesity-induced inflammation and insulin sensitivity in different tissues

Med Chem Res 34 , 22472268 (2025)

Carcinoma-associated fibroblasts: orchestrating the composition of malignancy

In contrast, treatment with IFN did not alter F4/80 levels in IFNGR1 KO MSRT1 cells (Fig

doi: [Google Scholar] 9.Gao Y, Wang L, Li X