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Enhanced delivery of vitamin C to the hypoxic core of solid tumors would facilitate down-regulation of the HIF-driven hypoxic response (Kuiper and Vissers, 2014)

PDK4 leads to a reduction in PDH activity through PDH phosphate

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The total number of squares crossed by each rat (total crossing), the number of rearing (standing on two hind paws without touching the walls), and grooming were recorded