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In the past 5 years, the FDA issued an unprecedented 161 new approvals of therapeutic agents for various indications in adult patients with solid tumours

Proteomics and interactomics High-resolution proteomic technologies, including mass spectrometry and affinity purification coupled with mass spectrometry (AP-MS), enable systematic identification of proteinprotein interaction networks and post-translational regulatory nodes

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The Cellular Basis for Targeting of Ferroptosis in AML: Regulation of Ferroptotic Cell Death by Iron Metabolism, ROS Production and Lipid Metabolism in AML Cells Ferroptosis is a form of autophagy-initiated cell death caused by cargo-specific autophagy (i.e., ferritinophagy) [124] and it is, in addition, characterized by oxidative stress and altered lipid metabolism [123,124]