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Evidence from human studies and experimental models has linked cuproptosis to DCM

Advanced imaging techniques, such as MRI with iron-sensitive contrast agents, can help visualize iron accumulation in tissues

Patients were treated for 80 days with ALA (600 mg/day, treatment group) or with a placebo (control group)

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Alzheimers Dement (Amst) 2024;16(1):e12567-e12567 Minjae Kim, Yoo Sung Song, Kyunghwa Han, Yun Jung Bae, Ji Won Han, Ki Woong Kim Impaired Glymphatic Flow on Diffusion Tensor MRI as a Marker of Neurodegeneration in Alzheimer's Disease: Correlation with Gray Matter Volume Loss and Cognitive Decline Independent of Cerebral Amyloid Deposition