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10.1182/blood-2012-05-432088 85 Ventura-ClapierR.GarnierA.VekslerV

Research suggests that Akt-mediated eNOS phosphorylation may increase nitric oxide (NO) bioavailability within vascular tissue microenvironments, potentially supporting vasodilation, microvascular integrity, and organized angiogenic responses in tissues with limited baseline vascular supply such as tendon, ligament, and fibrocartilaginous structures

This effectively limits Pdh and Odh activity prompting the accumulation of pyruvate or 2-oxoglutarate which can quench ROS albeit with very slow kinetics (Mailloux et al., 2007, 2013a)

Turf toe: anatomy, diagnosis, and treatment

HF: Project administration, Writingreview and editing