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ATT and asarone activated extracellular signal-regulated kinase (ERK) and Akt, the two key kinase cascades in neurogenesis

current methods of hydrogen delivery, including inhalation and hydrogen-enriched water, exhibit significant variability in hydrogen concentration within brain tissues

10.1523/JNEUROSCI.4062-12.2013 41 MelisM.CarboniE.CaboniP.AcquasE

The results from this study may reveal an important basis underlying the gender-associated differences in the longevity and the susceptibility to certain age-related diseases, and also further suggest that the decreased synthesis, which is mainly due to the down regulation of GCL gene expression, may be responsible for the age-associated decline in GSH content

Persistent ER stress and UPR failure can lead to apoptosis and activation of inflammatory pathways like NF-B and MAPK, increasing pro-inflammatory cytokine production (72)