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We also developed methods to detect NLRP3 activation in 2D and 3D tissue using LPS, as a primer, and Nigericin, as an NLRP3 inflammasome activator [14, 35]

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Notably, supplementation with 5-HT has been shown to restore dysregulated tryptophan metabolism in mouse disease models, potentially offering a novel therapeutic strategy for pulmonary fungal infections (67)

The peptide shows negligible activity at related class B receptors including CRF, PTH, and secretin receptors, supporting its specificity for the incretinglucagon receptor family

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