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It is found in nearly every cell in the body, but it is most concentrated in the liver

Some indole derivatives exert synergistic protective effects through autophagy regulation

The maximum changes in intestinal morphology (including ileal villus length, crypt depth, submucosal thickness, and muscular layer thickness) occurred prior to the peak of uveitis, which coincided with the peak expression of intestinal Zonula-occludens-1 (ZO-1), increased production of antimicrobial peptides (AMPs), and a reduction in cytokine production

Notably, CA has been found to exhibit inhibitory effects on PDGF-BB-induced proliferation of VSMCs

In summary, by interacting with these targets, active ingredients in DME may contribute to the treatment of RA