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Circulating tumor DNA as a predictive biomarker for pathologic response after treatment with neoadjuvant immunotherapy for localized dMMR/MSI-H colorectal cancer

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Pioneer studies showed that PGE 2 targets one of its 4 receptors, the EP4 receptor, on MuSCs to stimulate their cell cycle entry and the rate of cell proliferation, in particular symmetric self-renewal 28,29