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AGEs/RAGE stimulation activates immune cells, resulting in NADPH oxidase (NOX) overexpression, which is a primary cytoplasmic source of free radicals and pro-inflammatory factors such as tumor necrosis factor- (TNF-), interleukin 1 (IL-1) and interleukin 6 (IL-6) 5,6,7,8

4.1 Copper overload triggers apoptosis Apoptosis, a type of programmed cell death, is marked by substantial alterations in cell morphology and the activation of specific caspase and mitochondrial control pathways (130)