Several mitochondria-targeted antioxidants, including mitoQ, mito-TEMPO, pyrroloquinoline quinone, and SkQl are in clinical trials for other age-related diseases ( Caenorhabditis elegans and mice ( Apoptosis The correlation of alveolar cell apoptosis and decreased lung surface area have been shown in emphysema ( Pseudomonas aeruginosa infection in mice which promoted alveolar re-epithelialization via S1PR2-YAP signaling ( Smooth Muscle Cell Proliferation In addition to endothelial dysfunction, pulmonary vascular remodeling characterized by increased smooth muscle cell proliferation and narrowing of the vascular lumen has been shown in smokers and to precede airspace enlargement in animal models of emphysema (92)
This causes more pathological features and potentially triggers other lytic cell death mechanisms like ferroptosis and pyroptosis, increasing the pathogenesis of intestinal diseases
pneumophila infection, we employed mass spectrometric analysis to probe PR-Ub in cells infected with relevant bacterial strains
You can look at Table 2 in the paper yourself
22nd International Society for Diseases of the Esophagus, World Congress for Esophageal Diseases, 2026
