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75,76 Although other sources of oxidants (H 2 O 2 ) than the electron transport chain have been identified in relation to fatty acid metabolism within mitochondria, 77,78 the formation of peroxynitrite as the critical oxidant for mitochondrial dysfunction requires superoxide, which is generated by the electron transport chain

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Thus, SSG does not simply suppress or promote apoptosis, but instead functions as a context-dependent redox rheostat that determines the threshold and direction of apoptotic signaling