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doi: 10.3390/ijms21207551 62

2.2 RA strain and culture The RA-YM strain was kindly donated by the State Key Laboratory of Agricultural Microbiology at Huazhong Agricultural University (Wuhan, China)

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Liver expressed antimicrobial peptide-2 (LEAP2) is also important in this neuroendocrine system, as it acts as an endogenous GHSR inverse agonist and antagonist [6]

This interaction not only antagonizes Kyn-induced AhR activation but also suppresses the expression of indoleamine 2,3-dioxygenase (IDO)1a key enzyme driving Trp catabolism to Kynand subsequent differentiation of Tregs, thereby reversing the immunosuppressive TME (112, 161)