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The peptide appears to promote mucosal healing through enhancement of epithelial cell proliferation and migration, restoration of tight junction integrity, and modulation of inflammatory responses within the gastrointestinal tract

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This also contributes to reduced food intake at subsequent meals

This dual action activates regenerative TGF- signaling while blocking fibrotic TGF-1/Smad2/3 pathways, demonstrating context-dependent regulatory sophistication

The cream also strongly stimulated dermal keratinocyte proliferation as determined by the histological analysis of biopsies [35]