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For instance, in breast cancer, E-cadherin has an unexpected regulatory ability in tumorigenicity and hypoxia responses: E-cadherin loss is associated with slower tumor growth and loss of hypoxia response genes, which lead to reduced glycolytic capacity

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Gut Pathog 15 , 30 (2023)

In studies related to non-small cell lung cancer, it has been observed that a reduction in amino acid metabolism, along with the inactivation of the mTOR signaling pathway, can lead to the exhaustion of CD8+ T cells, thereby diminishing the body's immune defense capabilities (91)