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For composite kidney outcomes, the HR was 0.52 (95% CI 0.330.83) with SGLT2is and 0.70 (95% CI 0.590.83) without SGLT2is ( P -value for interaction 0.38) (Table 3)

This process highlights the dual role of ROS in tumors 76 : while they may promote tumor evolution under specific conditions (e.g., inducing DNA damage, facilitating angiogenesis, and activating immunosuppressive pathways), they may also exert anti-tumor effects by triggering cell cycle arrest