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doi: 10.1080/15548627.2024.2319901 63 CoHKCWuCCLeeYCChenSH

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The present review article focuses on summarizing the physiological role of seleno-GPxs and their synthetic mimics (mainly organoselenium compounds) in the radiation response of preclinical model systems

Restoring the GSH/GSSG ratio can have profound stabilizing effects on these systems: Dysautonomia and POTS Flares: Neuroinflammation in the brainstem and hypothalamus can drive the autonomic dysfunction seen in Postural Orthostatic Tachycardia Syndrome (POTS)

Lymphatic targeting may be achieved via the delivery of macromolecular therapeutics (for example, proteins and peptides), small-molecule therapeutics in association with macromolecular carriers (for example, nanoparticles, polymers, liposomes and dendrimers) or small-molecule therapeutics that associate, in situ , with endogenous macromolecular constructs (for example, lipoproteins and proteins) or cells that are transported from interstitial tissues via lymphatic rather than blood capillaries