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In vascularized organ transplantation, ischemia-reperfusion injury (IRI) can develop due to abruptly restored blood flow and a sudden flux of oxygen, causing oxidative stress, inflammation, infiltration of immunocytes, and widespread tissue damage 8

The role of protein kinases in relation to immune system regulation is evident across the literature data

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This obligately reduced production of proinflammatory cytokines including but not limited to IL 1 and IL 6