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Description

In a murine model of melanoma overexpressing IL-12 (B16-IL-12), NKp46 + ILC3 were shown to infiltrate the tumor and mediate the upregulation of ICAM-1 and VCAM-1 adhesion molecules on tumor vessels leading to the generation of a pro-inflammatory microvascular environment (123)

Research is ongoing to better understand how oral delivery compares to other forms

241 As a degradation product of GLP-1(7-36), GLP-1(936) has a notable inhibitory effect on glucagon secretion, demonstrated in both in vitro and in vivo studies