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Biomimetic enzyme nanocomplexes and their use as antidotes and preventive measures for alcohol intoxication

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Even though this effect may be mediated by the insulin receptor, experimental KO mice for the insulin receptor gene show a potent glucose lowering effect of IGF-1, indicative that the hypoglycaemic effect is also mediated, in part, by its own IGF-1R

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In the placebo-controlled 12-week pivotal study, change from baseline in Positive and Negative Syndrome Scale 78 (PANSS) total score was statistically significant versus placebo at week 12, 67 and comparable efficacies were observed for the 2 dose groups (AL 441 mg every 4 weeks and AL 882 mg every 4 weeks