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Di Pietro G, Magno LA, Rios-Santos F

The double mutant pcs1pcs2 impaired in phytochelatin synthesis and the catabolism of glutathione conjugates 61,62 showed also a WT-like phenotype when exposed to AITC

Trends Biochem Sci

ROS-induced mitochondrial dysfunction and DNA damage, along with the inhibition of key redox transcription factors such as Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) may contribute to the persistence of symptoms in both ME/CFS and Long COVID (Jarrott et al., 2022)

Recent studies have demonstrated that the depletion of GSH can be obtained acting on the different steps of the GSH cycle, triggering mechanisms able to stimulate, as a final result, cancer cell death