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In cultured cells, curcumin has been shown to inhibit cytokine-induced NF-B activation at multiple steps, blocking IB degradation, nuclear translocation of NF-B (p65/RelA), and NF-B DNA binding, ultimately reducing downstream expression of inflammatory mediators such as interleukins and chemokines (Peng et al., 2021)

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The meeting provides an early glimpse into how regulatory bodies under the second Trump administration might approach the rapid rise of peptides that are not yet FDA-approved