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Although the term PEM allows one to deal with diagnostically challenging pigmented melanocytic tumors, for which a reliable distinction between melanoma and an unusual pigmented nevus is difficult or impossible by light microscopic examination alone, we caution against labeling lesions as PEM, which previously would have been diagnosed as benign EBN or pigmented dermal spindle and epithelioid cell nevus

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While its most prominent implication is related to sexual function, its mechanistic profile suggests potential relevance in multiple domains of research

This chapter seeks to address these issues and give pathologists a framework with which to handle these challenging specimens

additional controlled studies are warranted to define safety, dosing, and efficacy parameters in new contexts.