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In the rat, they represent only approximately 10% of the total number of OR, while in most other species (guinea pig, monkey, and human) they represent at least a third of the opioid binding population (Dhawan et al., 2012

doi: 10.1056/NEJMoa1905248 50 CampisiRNolascoSPelaiaCImpellizzeriPD'AmatoMPortacciAet al

Meridians and collaterals theory is the theoretical basis of acupuncture and moxibustion, tuina () and qigong (), and also has certain guiding significance for the various clinical disciplines of TCM