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Glutathione and Hypothyroidism: Restoring Redox Balance In hypothyroidism - whether autoimmune (Hashimoto's) or non-autoimmune - the reduced metabolic rate paradoxically also creates oxidative stress, through different mechanisms: *Reduced mitochondrial efficiency - slower metabolism generates more electron leakage and ROS per unit of energy produced *Impaired antioxidant enzyme activity - thyroid hormones regulate the expression of antioxidant enzymes including GPx and SOD

and performing natural history studies in diverse ALS populations, which may be able to serve as controls for future trials [317]

Ecotoxicol Environ Saf 183:109467 Sagit M, Korkmaz F, Grgen SG, Kaya M, Akcadag A, Ozcan I (2014) The protective role of thymoquinone in the prevention of gentamicin ototoxicity