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The copper(II) complex adds one copper ion (atomic mass approximately 64 daltons) plus typically a coordinated water or hydroxide molecule, depending on conditions, giving the complex an overall mass in the range of approximately 400-420 daltons

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For instance, CBD (1 and 2.5 M) significantly prevented the adhesion of HCT116 cells to endothelial cells and suppressed their invasiveness and migration via the GPR55 receptor [45]

The opposite problem occurs with concentrated compounds like GHK-Cu at 50 mg

As cells have not evolved intrinsic genetic programs to counteract synthetic assemblies, expelling accumulated nanostructures overwhelms cellular regulatory capacity