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Doctors arent sure why, but sometimes those dopamine-producing neurons become damaged, causing motor and non-motor symptoms

Other disorders must be ruled out, and a pattern to the vomiting must be identified

Louis, MO, USA), tetrahydrofuran (C 4 H 8 O, 99.9%,Cornaredo MI, Italy), donepezil hydrochloride (C 24 H 30 ClNO 3 , 98% (HPLC), Sigma Aldrich, Lu Wan Qu, Shanghai, China), streptozotocin (C 8 H 15 N 3 O 7 , 98% (HPLC), 265.22 g/mol, Sigma Aldrich, Saint Louis, MO, USA), citrate buffer (0.1 M, pH 4.5, Biodiagnostic, Egypt), O-acetylcholine iodide (C 7 H 16 INO 2 , 99%, 273.12 g/mol, BDH chemicals, Poole, Dorset, England), 5,5-Dithio-bis(2-nitrobenzoic acid) (C 14 H 8 N 2 O 8 S 2 , 98%, 396.36 g/mol, Corsham, England), ELISA kit for brain derived neurotrophic factor (BDNF) (Elabscience, Wuhan, Hubei, China), Commercial kits from biodiagnostic, Egypt were used for the measurement of MDA, GSH and SOD

Demographic features are described in Table 1