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After the HO-1-catalysed reaction, the iron is released from the haem group and is stored inside the ferritin.101 The expression of ferritin is regulated by the concentration of iron and the HO-1 activity.102 This protein plays a crucial role in diseases related to haemoproteins, as ferritin-deficient rats show notable renal damage,103 and it is a good serum marker for SCA.104 Plasma levels of Tf are also higher in ferritin-deficient rats that are subjected to rhabdomyolysis.103 Nrf2 Nrf2 is a transcription factor that controls the expression of several antioxidant genes such as HO-1 and ferritin.105,106 Under normal conditions, Nrf2 is found in the cytoplasm bound to its repressor Keap1, which is susceptible to changes in the redox state and is subjected to proteolytic degradation through the proteasome

doi: 10.1007/s10585-016-9780-3 121 MaRFengYLinSChenJLinHLiangXet al

Paroxetine (Paxil) Another very common antidepressant, paroxetine also increased GDNF release similarly to clomipramine [74]

Neuron 12 : 10311040

This creates an environment where other pathogenic bacteria, such as Prevotella, Gardnerella , Atopobium , and Mobiluncus , can proliferate