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In poorly differentiated tumor cells, the TCA cycle and pyruvate metabolic activities are significantly enhanced, and key metabolic nodes such as ATP-citrate lyase (ACLY) and lactate dehydrogenase A (LDHA) are finely regulated by transcription factors such as KLF12, ZNF281, and RELA through super enhancers

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Thus, identification of modifiable factors that affect the progression of prostate cancer is [something that deserves study]. So, researchers at Harvard took more than a thousand men with early stage prostate cancer, and followed them for a couple years to see if there was anything in their diet associated with a resurgence of the cancer, such as a spread to the bone

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