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mTOR activation has also been targeted in these patients, although its sole action seems not to have any effect and needs to be combined with VEGF inhibitors [116]

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5.11 Hypothermia Hypothermia, defined as an unintentional drop in body core temperature to 5% and twice the rate of placebo) reported in the controlled pediatric mania study were nausea, upper abdominal pain, somnolence, increased ammonia, gastritis and rash