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The Neelakantan 2018 study in Biochemical Pharmacology reported that 5-Amino-1MQ administration to C57BL/6 mice on a 60% kcal-from-fat high-fat diet produced concentration-dependent reductions in fat mass and adipose-tissue NNMT enzymatic activity without significant changes in lean mass or food intake [1]

Instead, it has to be converted by the body to a useable form which can take up to 48 hours

Circadian lipid synthesis in brown fat maintains murine body temperature during chronic cold

AOD-9604 also appears in cartilage repair research (originally investigated for osteoarthritis before pivoting to obesity), because the hGH fragment retains some regenerative signaling without the proliferative risks of full hGH

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