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Am J Epidemiol 152:11451153

Clinical candidates such as Roches Trontinemab (a TfR1-bispecific derivative of Gantenerumab) show rapid amyloid clearance and reduced amyloid-related imaging abnormalities (ARIA), reflecting improved distribution

Alternatively, adequate intake of B12-fortified foods can provide sufficient amounts

Unlike metformin, which has a well-documented association with reduced vitamin B12 absorption, tirzepatide has not demonstrated a similar pharmacological mechanism that would directly interfere with B12 metabolism or absorption in the terminal ileum