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Conclusion This study presents a highly effective protocol for pyrimidines

showed that in the absence of DNA, a member of the basic/helix-loop-helix/zipper family of DNA-binding proteins, transcription factor Max, is rapidly digested by several endoproteases, indicating an open and flexible structure of the protein in the unbound form (Cohen et al., 1995)

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At 6 months, the rate of decline in ALSFRS-R was less than what had been measured in a 3-month lead in period, though this was not statistically significant [163]