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Acute attacks GI symptoms: severe abdominal pain, nausea, vomiting, constipation Neurological abnormalities: polyneuropathies (nonspecific pain, weakness/fatigue, paresthesia, paresis), seizures, respiratory paralysis Autonomic dysfunction: tachycardia, hypertension Psychiatric abnormalities: hallucinations, disorientation, anxiety, insomnia Red-purple urine Chronic symptoms Most patients remain asymptomatic between attacks

Figure 7 Betaines efficacy relative to other common therapeutic agents Betaine exerts significant therapeutic and biological effects that are potentially beneficial for alleviating a diverse range of diseases (20)

Researchers should review all available literature and follow appropriate laboratory protocols before conducting investigational work

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nucleatum in various non-oral pathological tissues, such as DNA of these bacteria has been identified in colorectal cancer tissues, atherosclerotic plaques, and placental tissues (Cui et al., 2025