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Modulation of extracellular matrix deposition Excessive deposition of ECM in the lamina propria of oral mucosa is an important feature of OSF

Male Infertility associated with a Novel PRKAR1A Mutation in Carney Complex

Zhi et al., 2012

Because the hinge and latch hypothesis predicts that the wild-type-mutant heterodimer does not support Nrf2 ubiquitination, a heterozygous missense mutation would result in the 75% reduction of Keap1 activity