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SAMe is a methyl donor critical for the production of numerous compounds, including deoxynucleic acid (DNA), neurotransmitters (like serotonin), and myelin (the protective sheath around nerve cells)

PD-MCI) (Apostolova et al., 2012)

Elevated Ca 2+ levels in the cochlea may link to ROS production as well as triggering apoptotic and necrotic cell death pathways independent of ROS formation (Orrenius et al., 2003)

Discontinuation may be necessary for severe hematologic or other toxicity, even if rejection of the homograft may be a consequence of drug withdrawal

Morse GD, Holdsworth MT, Venuto RC, Gerbasi J, Walshe JJ