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Exosome-like nanovectors for drug delivery in cancer

10.3390/ijms21197213 146

461 However, metformin may interfere with the improvement of some physiological functional parameters, such as whole-body insulin sensitivity and cardiorespiratory fitness, and may have a negative effect on the hypertrophic response in healthy elderly individuals

Combining hepsin with relatively low doses of N-acetylcysteine had a synergistic effect that was more efficacious than high-dose N-acetylcysteine alone

The evidence base for the stack consists of mechanism-level inference, two small trials for the individual agents [1][2], and practitioner-reported outcomes