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Histamine intolerance (HIT / adverse reactions to ingested histamine): A suggested non-IgE pathology is a defective capacity to degrade histamine, frequently by way of the reduced histamine degradation capacity, intestinal DAO deficiency, or impaired methylation resulting in the histamine buildup and multi-system often unspecialized symptoms

When AGEs bind to RAGE, they trigger: Cytokine and growth factor release (e.g., TGF- and VEGF), leading to basement membrane thickening and diabetic retinopathy

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Kim DW, Tan EY, Jin Y et al , Effects of imatinib mesylate on the pharmacokinetics of paracetamol (acetaminophen) in Korean patients with chronic myelogenous leukaemia