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The glutathione levels of young rat cells never decreased to less than 35 percent of its initial level, whereas in older rat cells glutathione levels plummeted to 10 percent of their original level

This oxidation protocol is superior to the previously reported approaches, namely PIFA gives complex mixtures of products and a lower yield of 7OH, while lead tetraacetate involves a toxic heavy metal and requires a second hydrolysis step 75

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In the presence of FDX1 and adequate copper, cuproptosis is induced by delivering extracellular Cu into cells [56]