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Mathapati S, Siller R, et,al

10.1093/nar/gks1104 Nucleic Acids Res

In addition to its direct antioxidant functions, glutathione (GSH) contributes to the regeneration of other antioxidants, including vitamins C and E, and is involved in critical processes such as iron homeostasis and mitochondrial integrity

FIGURE 3 6.1 Avascularity and nutrient deficiency The intervertebral disc (IVD) is the largest avascular tissue in the human body, and its cells depend on the diffusion of nutrients from surrounding blood vessels through the cartilage endplate (CEP) into the tissue interior