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4.3 Potential effects of gut metabolites on ferroptosis in OA 4.3.1 Gut metabolites inhibiting ferroptosis mechanisms 4.3.1.1 Tryptophan metabolites suppress ferroptosis via antioxidant mechanisms Tryptophan metabolites serve as pivotal mediators in host-microbiota interactions and are closely linked to systemic inflammatory and immune processes (Gaspar et al., 2025)