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The first responding cells are microglia and adult oligodendrocyte precursor cells (OPC), which migrate towards the lesion, with astrocyte responses to follow

Development was discontinued because the Phase IIb trial of 536 subjects over 24 weeks failed to meet its primary efficacy endpoint

So, we should, in theory, be able to target that protein from lots of different parasitic worms with this approach. References Steinmann, P., Keiser, J., Bos, R., Tanner, M., & Utzinger, J

The mechanisms and management of age-related oxidative stress in male hypogonadism associated with non-communicable chronic disease

Nevertheless, given its widespread use, hydrochlorothiazide (HCTZ) is another frequently reported causes of phototoxicity [49,132,201]