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AcAc acetoacetate AF atrial fibrillation BDH D--hydroxybutyrate dehydrogenase -OHB -hydroxybutyrate cPHB complexed poly--hydroxybutyrate FFAR3 free fatty acid receptor 3 FOXO3a Forkhead box O3a GPCRs G-protein-coupled receptors IDL intermediate density lipoproteins HDACs class I histone deacetylases HF heart failure HMG-CoA -hydroxy--methylglutaryl-CoA LCKD low carbohydrate ketogenic diet LDL low density lipoproteins LFI low flow ischemia PHB poly--hydroxybutyrate polyP inorganic polyphosphate SCOT succinyl-CoA:3-oxoacid-CoA transferase TCA tricarboxylic acid VLDL very low density lipoproteins