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In Anopheles gambiae , residues in the H-site of AgGSTe2 were presumptively responsible for DDT binding and they were mostly hydrophobic residues [84]

10.1016/j.mtchem.2022.100808 127 SharmaP.PatnalaK.SahN.DebV

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This phosphorylates and inhibits GFPT1, thereby weakening YAP protein stability and the transcription of its downstream target gene FTH1, ultimately promoting ferritinophagy, lipid peroxidation, and enhanced ferroptosis susceptibility ( Figure 3 Besides glutamine, arginine metabolism also plays a complex role in ferroptosis regulation